- Visibility 209 Views
- Downloads 31 Downloads
- Permissions
- DOI 10.18231/2394-4994.2018.0002
-
CrossMark
- Citation
To compare intravenous paracetamol with tramadol given pre-emptively for intraoperative and postoperative analgesia- A randomized controlled trial
- Author Details:
-
Anuja Agrawal
-
Mridul M. Panditrao
-
Smita Joshi
Introduction: The recommended approach for postoperative pain management is to initiate the treatment with analgesics such as paracetamol, NSAIDS, and aspirin followed by adjunctive use of opioids to treat more acute pain symptoms. However, the adverse effects associated with opioids and NSAIDS are well established.
Aim: To study the efficacy of paracetamol in comparison to Tramadol when used as analgesic component of balanced anesthesia, pre-emptively for intraoperative and postoperative purpose. To study their side effects. To find out which of these two drugs is better in providing intraoperative and postoperative analgesia with minimum side effects.
Materials and Methods: 60 patients of either sex, divided using computer generated random number table into 2 equal groups. Group T: (n 30): Tramadol hydrochloride group, Group P: (n 30): Paracetamol group. The dose of paracetamol and tramadol hydrochloride was 15mg/kg and 2mg/ kg body weight respectively. Statistical analysis: analysis was done by SPSS software version 11 by using Z test, chi-square test, proportion test (Z). P value less than 0.05 was considered as significant and less than 0.0001 as highly significant.
Results: Both the groups were comparable with respect to their demographic profile, ASA status, and surgical procedures. Both paracetamol and tramadol have a good analgesic action and fewer side effects. The mean score of VAS Scale in group P (1.86  2.40) and group T (3.03  2.42) was similar and difference was not statistically significant. Also the side effects were comparable in both groups. Total number of rescue analgesics required by the group P (1.6) was significantly less as compared to the group T (3.7) with Z value = 4.00, p < 0.0001.
Conclusion: Paracetamol has a better efficacy than tramadol hydrochloride in providing intra-operative and post-operative analgesia, when used pre-emptively with reduced number of doses of analgesic and almost no side effects.
Keywords: Analgesia, Paracetamol, Post-operative Preemptive, Tramadol.
References
- Vadivelu N, Mitra S, NarayanD. Recent Advances in Postoperative Pain Management.Yale J Biol Med. 2010 Mar;83(1):11–25.
- Royal College of Surgeons of England/ College of Anesthetists. Commission on the provision of surgical services: report of working party on pain after surgery. London: Royal College of England/ College of Anesthetists, 1990.
- Breivik H; ‘Benefits, risks and economics of post- operative pain management programmes’ In Breivik H (ed.). Bailliere’s clinical anesthesiology. Post-operative Pain Management 1995;9:403-22.
- Parkhouse J, Simpson BRJ; The Problem of Postoperative Pain. British Journal of Anaesthesia 1961;33:336-43.
- Breivik H, Stubhaug A. Management of acute postoperative pain: still a long way to go! Pain. 2008;137(2):233–34.
- ScottJ, Huskisson EC. Vertical or horizontal visual analogue scales. Ann Rheum Dis 1979;38:560.
- Ahmed AU, Islam SM, Islam SM, et al. Effect of preemptive intravenous ketorolac and bupivacaine infiltration on post operative pethidine consumption - a comparative study. Journal of the Bangladesh Society of Anaesthesiologists. 2010:23:25-9.
- Meyer RA, Campbell JN; ‘Peripheral mechanisms at nociception’. In Textbook of Pain, 3 rd edition, Wall RD, Melzack R: Churchill Livingston, New York, 1994:357–
- Bachiocco V, Scesi M, Morselli AM, Carli G. Individual pain history and familial pain tolerance models: relationships to post-surgical pain. Clin J Pain. 1993;9:266–71.
- Taenzer P, Melzack R, Jeans ME. Influence of psychological factors on postoperative pain, mood and analgesic requirements. Pain. 1986;24:331–42.
- Woolf CJ, Chong MS. Preemptive analgesia—treating postoperative pain by preventing the establishment of central sensitization. AnesthAnalg 1993;77:368
- Arslan, Mustafa et al. “Comparing the Efficacy of Preemptive Intravenous Paracetamol on the Reducing Effect of Opioid Usage in Cholecystectomy.”Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences 18.3 (2013):172–
- Arici S, Gurbet A et al. Preemptive analgesic effects of intravenous paracetamol in total abdominal hysterectomy. Agri. 2009 Apr;21(2):54-61.
- S. Aghamir, M. Mojtahedzadeh, F. Alizadeh, H. Khalili, M. Sadeghi, A. Najafi, K. Rezaie, F. Rafizadeh& F. Shabani : Propacetamol Vs. Tramadol For Post-Operative Pain Management After Urologic Surgery . The Internet Journal of Pharmacology. 2006 Volume 4 Number 2.
- Aporado CB, Tantri L, Tanchoco L (2015) The Analgesic Efficacy of Tramadol as a Pre-Emptive Analgesic in Pediatric Appendectomy Patients. MOJ Surg 2(3): 00021. DOI: 10.15406/mojs.2015.02.00021
[Google Scholar]
How to Cite This Article
Vancouver
Agrawal A, Panditrao MM, Joshi S. To compare intravenous paracetamol with tramadol given pre-emptively for intraoperative and postoperative analgesia- A randomized controlled trial [Internet]. Indian J Clin Anaesth. 2018 [cited 2025 Oct 03];5(1):9-12. Available from: https://doi.org/10.18231/2394-4994.2018.0002
APA
Agrawal, A., Panditrao, M. M., Joshi, S. (2018). To compare intravenous paracetamol with tramadol given pre-emptively for intraoperative and postoperative analgesia- A randomized controlled trial. Indian J Clin Anaesth, 5(1), 9-12. https://doi.org/10.18231/2394-4994.2018.0002
MLA
Agrawal, Anuja, Panditrao, Mridul M., Joshi, Smita. "To compare intravenous paracetamol with tramadol given pre-emptively for intraoperative and postoperative analgesia- A randomized controlled trial." Indian J Clin Anaesth, vol. 5, no. 1, 2018, pp. 9-12. https://doi.org/10.18231/2394-4994.2018.0002
Chicago
Agrawal, A., Panditrao, M. M., Joshi, S.. "To compare intravenous paracetamol with tramadol given pre-emptively for intraoperative and postoperative analgesia- A randomized controlled trial." Indian J Clin Anaesth 5, no. 1 (2018): 9-12. https://doi.org/10.18231/2394-4994.2018.0002