- Visibility 523 Views
- Downloads 475 Downloads
- Permissions
- DOI 10.18231/j.ijca.2025.075
-
CrossMark
- Citation
Comparison of the efficacy of intravenous dexamethasone, betamethasone gel and lignocaine jelly in reducing postoperative sore throat among prone-positioned patients
Background and Objectives: Post-operative sore throat (POST), post extubation cough (PEC) and hoarseness of voice (HOV) are common post operative complications causing patient dissatisfaction and morbidity. The etiology of POST is multifactorial that includes patient positioning, as shifting from supine to prone cause displacement of the endotracheal tube (ETT). This study aimed to compare the efficacy to reduce POST, PEC and HOV between intravenous dexamethasone, betamethasone gel and lignocaine jelly among prone positioned patients.
Methodology: Ninety patients aged between 18-60 years, American society of anaesthesiologists (ASA) class I and II undergoing elective spine surgeries in prone position under general anaesthesia were randomly assigned into three groups of 30 each. ETT was lubricated with 0.05% betamethasone gel in Group-B, 2% lignocaine jelly in Group-L and intravenously 0.2mg/kg dexamethasone was given in Group-D. The occurrence of postoperative sore throat, post-extubation cough, and hoarseness of voice was evaluated at 1, 6, 12, and 24 hours after surgery.
Results: Among Group B, D and L the incidence of POST was 0%, 26.7% and 50% at 12 hours respectively and 0%, 20% and 60% at 24 hours respectively. Betamethasone had statistically significant lowest POST incidence (B vs D, p=0.01 at 12 hours; 0.03 at 24 hours; B vs L, p<0 p=0.002).>
Conclusion: Betamethasone gel effectively reduces POST, PEC, and HOV in patients undergoing prone positioning during surgery when compared to intravenous dexamethasone and lignocaine jelly.
Keywords: Betamethasone; Lignocaine; Dexamethasone; Post operative sore throat; Post extubation cough; Hoarseness of voice.
References
- Yang N, Tao Q, Niu J, Yu J. Postoperative sore throat after general anaesthesia: a narrative review. J Anaesthesiol Transl Med. 2023;2(3):34–4.
- Im A, Sagita S, Dedi ME. Intratracheal lidocaine reduces incidence of cough during extubation and sore throat after tonsillectomy surgery: a randomized, single-blind clinical trial. Bali J Anaesthesiol. 2022;6(2):75.
- Zuccherelli L. Postoperative upper airway problems: a review. Southern Afr J Anaesth Analg. 2003;9(2):12–6.
- Sheikh SA, Mir AH, Yousuf A, Naqash IA. Evaluation of efficacy of intravenous magnesium sulphate versus dexamethasone for prevention of postoperative sore throat in patients undergoing lumbar spine surgery in prone position: a prospective randomized double blind placebo controlled study. Int J Adv Med. 2019;6(3):833–9.
- Mandal M, Bagchi D, Das S, Sahoo T, Basu S, Sarkar S. Efficacy of intravenous dexamethasone to reduce incidence of postoperative sore throat: a prospective randomized controlled trial. J Anaesthesiol Clin Pharmacol. 2012;28(4):477–80.
- Smitha S. Efficacy of prophylactic intravenous dexamethasone on postoperative laryngotracheal symptoms after orotracheal extubation: a randomized study. Panacea J Med Sci. 2023;13(2):525–31.
- Thapa P, Shrestha RR, Shrestha S, Bajracharya GR. Betamethasone gel compared with lidocaine jelly to reduce tracheal tube related postoperative airway symptoms: a randomized controlled trial. BMC Res Notes. 2017;10(1):361.
- Singh G, Jadeja P, Patnaik RY, Ravinbothayan S, Singh V, Dhawan R. Comparative Study between Betamethasone Gel and Lignocaine Jelly Applied Over the Tracheal Tube to Reduce Postoperative Airway Complications. Bali J Anesthesiol. 2021;5(1):11–4.
- Soltani HA, Aghadavoudi O. The effect of different lidocaine application methods on postoperative cough and sore throat. J Clin Anaesth. 2002;14(1):15–8.
- Lee J, Lee YC, Son JD, Lee JY, Kim HC. The effect of lidocaine jelly on a taper-shaped cuff of an endotracheal tube on postoperative sore throat. Medicine. 2017;96(37):1–7.
- Lee SH, Lee YC, Lee JH, Choi SR, Lee SC, Lee JH, et al. The prophylactic effect of dexamethasone on postoperative sore throat in prone position surgery. Korean J Anaesthesiol. 2016;69(3):255–60.
- Tabari M, Soltani G, Zirak N, Alipour M, Khazaeni K. Comparison of effectiveness of betamethasone gel applied to the tracheal tube and IV dexamethasone on postoperative sore throat: a randomized controlled trial. Iran J Otorhinolaryngol. 2013;25(4):215–20.
- Kazemi A, Amini A. The effect of betamethasone gel in reducing sore throat, cough, and hoarseness after laryngo-tracheal intubation. Middle East J Anaesthesiol. 2007;19(1):197–204.
- Ayoub CM, Ghobashy A, Koch ME, McGrimley L, Pascale V, Qadir S, et al. Widespread application of topical steroids to decrease sore throat, hoarseness, and cough after tracheal intubation. Anesth Analg. 1998;87(3):714–6.
- Sumathi PA, Shenoy T, Ambareesha M, Krishna HM. Controlled comparison between betamethasone gel and lidocaine jelly applied over tracheal tube to reduce postoperative sore throat, cough, and hoarseness of voice. Br J Anaesth. 2008;100(2):215–
- Upadhyay N, Gupta R, Prakash S, Bhalla S. Controlled comparison between betamethasone gel and lidocaine jelly applied over endotracheal tube in reducing postoperative sore throat, cough, and hoarseness of voice. Indian Anaesth Forum. 19(2):65–72.
- Kiran S, Goel M, Singhal P, Gupta N, Bhardwaj M. Postoperative sore throat with 0.05% betamethasone gel and 2% lignocaine jelly used as a lubricant for ProSeal LMA (PLMA) insertion. Egypt J Anaesth. 2012;28(2):139–42.
- Thomas S, Beevi S. Dexamethasone reduces the severity of postoperative sore throat. Can J Anaesth. 2007;54(11):897-901.
- Kuriyama A, Maeda H. Preoperative intravenous dexamethasone prevents tracheal intubation-related sore throat in adult surgical patients: a systematic review and meta-analysis. Can J Anaesth. 2019;66:562–75.
- Mohammed N, Rashad AE. Lidocaine versus dexamethasone for reduction of sore throat after general anesthesia: a comparative study. Res Opin Anesth Intensive Care. 2022;9:297–301.
- Subedi A, Tripathi M, Pokharel K, Khatiwada S. Effect of intravenous lidocaine, dexamethasone, and their combination on postoperative sore throat. Anesth Analg. 2019;129(1):220–5.
- Williams DM. Clinical pharmacology of corticosteroids. Respir Care. 2018;63(6):655–70
- Yang N, Tao Q, Niu J, Yu J. Postoperative sore throat after general anaesthesia: a narrative review. J Anaesthesiol Transl Med. 2023;2(3):33–4
- Padhi S, bhat S. An experimental study on tropical application of 2% lignocaine jelly for preventing coughing and sore throat post extubation in elective surgeries in smokers vs. non smokers. Biomed Pharmacol J. 2020;13(1):291–8
- Liao AH, Yeoh SR, Lin YC, Lam F, Chen TL, Chen CY. Lidocaine lubricants for intubation-related complications: a systematic review and meta-analysis. Can J Anaesth. 2019;66(10):1221–39.
- Maab H, Mustafa F, Ali SA. Anti-inflammatory aspects of Lidocaine: a neglected therapeutic stance for COVID-19. Heart Lung. 2020;49(6):877–8
- Hossain MS, Rashid M, Babu RA, Saha D, Banik D. Betamethasone gel versus intravenous dexamethasone as prophylaxis against postoperative sore throat. Delta Med Col J. 2018; 6(2):73–7.
How to Cite This Article
Vancouver
R B, Murdeshwar GN. Comparison of the efficacy of intravenous dexamethasone, betamethasone gel and lignocaine jelly in reducing postoperative sore throat among prone-positioned patients [Internet]. Indian J Clin Anaesth. 2025 [cited 2025 Oct 02];12(3):484-491. Available from: https://doi.org/10.18231/j.ijca.2025.075
APA
R, B., Murdeshwar, G. N. (2025). Comparison of the efficacy of intravenous dexamethasone, betamethasone gel and lignocaine jelly in reducing postoperative sore throat among prone-positioned patients. Indian J Clin Anaesth, 12(3), 484-491. https://doi.org/10.18231/j.ijca.2025.075
MLA
R, Bismi, Murdeshwar, Greeshma N. "Comparison of the efficacy of intravenous dexamethasone, betamethasone gel and lignocaine jelly in reducing postoperative sore throat among prone-positioned patients." Indian J Clin Anaesth, vol. 12, no. 3, 2025, pp. 484-491. https://doi.org/10.18231/j.ijca.2025.075
Chicago
R, B., Murdeshwar, G. N.. "Comparison of the efficacy of intravenous dexamethasone, betamethasone gel and lignocaine jelly in reducing postoperative sore throat among prone-positioned patients." Indian J Clin Anaesth 12, no. 3 (2025): 484-491. https://doi.org/10.18231/j.ijca.2025.075