Correlation Between Presepsin, Procalcitonin, and C-Reactive Protein Levels with Sequential Organ Failure Assessment (SOFA) Scores in Sepsis Patients at the Intensive Care Unit (ICU)

Authors: Novita Anggraeni, Nopian Hidayat, Ricko Yorinda Putra, Dhita Natasha Dwiriyanti Hardi, Fridayenti Fridayenti

DOI: 10.18231/j.ijca.11977.1758706144

Keywords: SOFA scores,sepsis,presepsin,procalcitonin,CRP

Abstract: Aim and objective: This study investigates the correlation between these biomarkers and SOFA scores in ICU patients with sepsis. Introduction: Sepsis is a life-threatening condition caused by infection, often leading to organ dysfunction and increased mortality. Biomarkers like presepsin, procalcitonin, and C-reactive protein (CRP) are crucial for diagnosing and predicting sepsis outcomes. Methods: Using a prospective observational design, the study involved sepsis patients admitted to the ICU this hospital. Biomarker levels were measured from the first to the third day of treatment, alongside SOFA score assessments. Results: Statistical analysis revealed significant correlations between presepsin, procalcitonin, and CRP levels with SOFA scores. Presepsin showed superior prognostic value in evaluating organ dysfunction compared to procalcitonin and CRP. Conclusion: These findings highlight presepsin as an effective early biomarker for sepsis diagnosis and severity assessment. Further research is recommended to confirm its broader application in clinical practice in Indonesia.