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To assess the effect of oral melatonin premedication on propofol requirement for induction in entropy guided general anaesthesia- A randomised double blind study

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Original Article

Author Details : Nethra S.S, Ranjitha Gangadharaiah*, Shubha , Sudheesh K, Devika Rani

Volume : 6, Issue : 3, Year : 2019

Article Page : 410-414

https://doi.org/10.18231/j.ijca.2019.079

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Abstract

Introduction: Premedication plays an important role in providing anxiolysis prior to surgery, reduce the intraoperative requirement of intravenous anesthetics and manage perioperative pain. Melatonin premedication has been shown to allay pre-operative anxiety, produce postoperative sedation and reduce analgesic requirement. This study aims to assess the effect of oral melatonin premedication on propofol requirement for induction of anaesthesia.
Materials and Methods: A randomized double blind study was performed on 70 patients of American Society of Anaesthesiologists (ASA) I and II status after obtaining ethical committee clearance. Patients received 3 mg oral melatonin (group M) or placebo (group C) as premedication 60 min prior to surgery (n= 35 in each group). The requirement of propofol for induction was noted using entropy. Patients were assessed for preoperative anxiety using Hamilton anxiety rating scale (HAM) and peri-operative sedation using Ramsay sedation scale (RSS).
Results: The demographic variables were comparable between the 2 groups. There was significant difference between the mean propofol dose requirements for induction in group M and C i.e., 0.96 ± 0.1mg/kg and 2 ± 0.26 mg/kg respectively, with p < 0>
Conclusion: Oral melatonin premedication reduces the induction dose of propofol.

Keywords: Melatonin, Anxiety, Sedation, Propofol consumption.

How to cite : S.s N, Gangadharaiah R, Shubha, Sudheesh K, Rani D, To assess the effect of oral melatonin premedication on propofol requirement for induction in entropy guided general anaesthesia- A randomised double blind study. Indian J Clin Anaesth 2019;6(3):410-414

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