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Effects of magnesium sulphate on intraoperative neuromuscular blocking agent requirement: A prospective randomized double blind placebo controlled study

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Original Article

Author Details : Aabid Hussain Mir, Juvera Gul Wani, Abida Yousuf*, Sheikh Irshad, Zahoor Ahmad Shah

Volume : 6, Issue : 3, Year : 2019

Article Page : 355-358

https://doi.org/10.18231/j.ijca.2019.068

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Abstract

Introduction: Magnesium sulphate has been shown to decrease intraoperative anesthesia, analgesia and muscle relaxant requirements.
Aims: To study the effects of intraoperative magnesium sulphate on requirement of neuromuscular blocking agents.
Setting and Design: This prospective randomized double blind placebo controlled study was conducted in the department of Anaesthesiology and Critical Care of a tertiary care centre.
Materials and Methods: 50 patients of ASA physical status I and II were randomly allocated into two groups, magnesium group (Group M) received magnesium sulphate 50 mg.kg^-1 intravenously as a bolus in 100 ml of isotonic saline over 10 minutes before induction of anesthesia and 15 mg.kg^-1h^-1 by continuous infusion during the operation and the control group (Group S) received the same amount of isotonic saline over same time. Atracurium was administered 0.6 mg.kg^-1 before intubation and 0.1 mg.kg^-1 additionally when train-of-four counts were 2 or more intravenously. The consumption of atracurium was compared in both groups.
Statistical Analysis: The variables were analysed with independent t-test, Wilcoxon-Mann Whitney U- test and chi-square test. P-value<0> Results: The mean consumption of atracurium in group M was 0.35±0.11 mg.kg^-1h^-1 and group S was 0.47±0.19 mg.kg^-1h^-1 with p-value<0> Conclusion: Intravenous magnesium sulphate reduces atracurium requirements in patients undergoing abdominal surgeries under general anesthesia.

Keywords: Neuromuscular blocker, Intraoperative, Magnesium, Atracurium.

How to cite : Mir A H, Wani J G, Yousuf A, Irshad S, Shah Z A, Effects of magnesium sulphate on intraoperative neuromuscular blocking agent requirement: A prospective randomized double blind placebo controlled study. Indian J Clin Anaesth 2019;6(3):355-358

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