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Effects of preoperative single bolus dose of dexmedetomidine on perioperative hemodynamics in elective laparoscopic cholecystectomy

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Author Details : P Indira, Rajola Raghu*, A Swetha

Volume : 6, Issue : 1, Year : 2019

Article Page : 47-54

https://doi.org/10.18231/2394-4994.2019.0010

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Abstract

Minimal surgical access techniques have become a gold standard of patient care in present era, laparoscopic cholecystectomy is preffered treatment of choice for gall stones. Along with advantages, it is also associated with severe sympathoadrenal stress response, a cause for morbidity and mortality. Dexmedetomidine is an highly selective alpha2 adrenoceptor (?2-AR) agonist, seems to control this sympathetic response and provide a stable perioperative haemodynamics.
Aim of the Study: To investigate effects of preoperative single bolus dose of Dexmedetomidine on hemodynamic parameters in patients posted for Elective Laparoscopic Cholecystectomy.
Design: Randomised Prospective Double-Blind Study.
Materials and Methods: 50 ASA Gr I & II patients belonging to both sex in age group of 20 to 50yrs scheduled for Elective Laparoscopic Cholecystectomy were randomly divided into two groups of 25 each Group-D (Dexmedetomidine) and Group – S (Placebo (0.9% Saline)) A Balanced General Anaesthesia technique included Propofol, Vecuronium IPPV & Isoflurane 0.5%. Perioperatively SBP, DBP, MAP, HR were recorded at predetermined intervals - Pre-op, After Induction, After Intubation & 15 mins interval and extubation data was analysed statistically.
Results: In Group D - HR, MAP, SBP, DBP were significantly less in comparision to Group S.
Conclusion: A single bolus dose of Dexmedetomidine preoperatively effectively attenuates sympathoadrenal stress responses to laparoscopy results in stable perioperative hemodynamics.

Keywords: CO₂ insufflation, Stress response, Dexmedetomidine, ?₂- adrenoceptor agonist.

How to cite : Indira P, Raghu R, Swetha A, Effects of preoperative single bolus dose of dexmedetomidine on perioperative hemodynamics in elective laparoscopic cholecystectomy. Indian J Clin Anaesth 2019;6(1):47-54

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