---

Effect of Intravenous Dexmedetomidine on Bupivacaine for Spinal Anaesthesia

Full Text PDF Share on Facebook Share on Twitter

---

Original Article

Author Details : Olvyna D’Souza, Amarjeet Dnyandeo Patil, Nitin Kapoor

Volume : 4, Issue : 4, Year : 2017

Article Page : 428-434

Suggest article by email

Get Permission

Abstract

 Since the discovery of spinal anaesthesia, it has been used widely with different additives in local anaesthetic drugs. Vasoconstrictors like phenylephrine, opioids, neostigmine and clonidine are some of the well known agents used to prolong the duration of block; whereas hypnotic, sedative and amnesic drugs are required to reduce the discomfort. However, they affect the ventilatory mechanisms and may lead to respiratory depression, with consequent hypercarbia and hypoxemia.
A promising alternative to these drugs in anaesthesiology is the group of alpha-adrenergic agonist, which have excellent sedative and analgesic properties without respiratory depression. Clonidine an alpha 2 agonist has been used widely in the intrathecal route oral and intravenous routes to prolong the duration of spinal anagesia. dexmedetomidine, also an alpha 2 agonist, has eight times more affinity for alpha 2 receptors than does clonidine and has been used for pre-medication and as an adjunct to general anaesthesia. Various studies show that intravenous dexmedetomidine prolonged the sensory and motor blockade of bupivacaine spinal anaesthesia with good sedation and hemodynamic stability. The present study is designed to study the effect of intravenous dexmedetomidine with a loading dose of 1µg/kg and a maintenance dose of 0.5µg/kg on bupivacaine spinal anaesthesia with respect to duration of sensory and motor blockade, level of sedation and hemodynamic stability.

Keywords: Intravenous dexmedetomidine, Bupivacaine, Spinal anaesthesia.

How to cite : D’souza O, Patil A D, Kapoor N, Effect of Intravenous Dexmedetomidine on Bupivacaine for Spinal Anaesthesia. Indian J Clin Anaesth 2017;4(4):428-434

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.