A COMPARATIVE STUDY OF IV LIGNOCAINE VS ORAL CLONIDINE FOR ATTENUATION OF HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION
Full Text PDF
Original Article
Author Details :
Abhishek Chatterjee, D.P.Samaddar, Srividhya, Deb Sanjay Nag, Nishant Sahay
Volume : 2, Issue : 1, Year : 2015
Article Page : 41-47
Suggest article by email
Get Permission
Abstract
Background: Laryngoscopy and tracheal intubation induce potentially harmful hemodynamic
response. None of the advocated methods had been accepted as the most effective option. Ease of
use and economical advantages of the suggested methods are also important considerations. This
study was designed to address this concern by using two common drugs (intravenous lignocaine
vs.oral clonidine).
Material and Method: A randomized, controlled, prospective, single blind study was planned
involving 70 patients divided equally into two groups – Group C (patients received oral Clonidine 4
mcg/kg 90 minutes prior to intubation) and Group L (Patients received intravenous Lignocaine 2
mg/kg 3 minutes prior to intubation).
Observations: Focus was on hemodynamic parameters - Heart rate, Systolic, Diastolic, Mean
blood pressures and Rate pressure product, however, sedation and anxiety score was also
compared.
Results: Demographic profile and time taken for intubation was same in both the groups. Post
intubation rise (>25 % from base line) in heart rate was observed more in Gr.L (54.28 %) as
compared to 5.71 % in Gr.C. Systolic, diastolic and mean arterial blood pressure variations were
observed more in Gr L (42.85 %, 25.71 % and 22.85%) as compared to Gr. C (2.85 %, 5.71 % and
2.85 % ). Difference for all the above parameters was statistical significant (p-value < 0.05).
However 40 % of patients were drowsy, 82.85 % of patients had dryness of mouth, two patients
(5.71 %) had bradycardia and hypotension in Clonidine group, whereas such observations were
not made in Lignocaine group.
Conclusion: Oral Clonidine at a dose of 4 mcg/kg body weight (up to a maximum limit of 200 mcg)
therefore can be considered as better option than time tested intravenous Lignocaine
Key Words: Anaesthesia, Intubation response, Effective attenuation of laryngoscpic response,
Lignocaine, Clonidine
How to cite :
Chatterjee A, D.p.samaddar, Srividhya, Nag D S, Sahay N, A COMPARATIVE STUDY OF IV LIGNOCAINE VS ORAL CLONIDINE FOR ATTENUATION OF HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION. Indian J Clin Anaesth 2015;2(1):41-47
This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
