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A randomized placebo controlled trial on evaluation of the efficacy of two different doses of pregabalin as a pre-emptive analgesia in gynaecological surgeries

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Original Article

Author Details : Priti M. Patel, Rakesh D. Panchal, Bipin M. Patel

Volume : 3, Issue : 4, Year : 2016

Article Page : 576-582

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Abstract

Background: Pre-incisional analgesia has been shown to be more effective in control of postoperative pain by protecting central nervous system from deleterious effects of noxious stimulus and resulting allodynia and increased pain. Anti-hyperalgesic and antiallodynic properties of pregabalin improve postoperative pain by preventing the development of central sensitization. This study was designed to compare the efficacy of two different doses of Pregabalin with that of placebo in reducing post-operative pain, analgesic requirement, prolongation of analgesia and side effects.
Method: Ninety female patients of ASA grade ? & ?? undergoing gynaecological surgeries were randomly divided in three groups of thirty each. Patients received Pregabalin 150 mg (P₁), Pregabalin 300 mg (P₂) and placebo (P₀) one hour before surgery. Post-operatively parameters observed were visual analogue score (VAS) and sedation score, time to first analgesic requirement, total analgesic consumption and side effects for first 24 hours.
Result: VAS score were lower in the Pregabalin group as compared to placebo group. Sedation score was highest with Pregabalin 300 mg as compared to other two groups. Time to first rescue analgesia was 6.97±1.351 hours in group P₁, 8.47±1.408 hours in group P₂ as compared to 3.1±1.604 in placebo group. Mean number of total doses of rescue analgesics in first 24 was 1.67±0.711 hours in group P₁, 1.2±0.407 in group P₂ as compared to 2.97±0.668 in group P_0. Side effects like visual disturbance and dizziness were higher in group P₂ as compared to other two groups.
Conclusion: Pre-emptive pregabalin provide batter analgesia post operatively than placebo group. While 300mg pregabalin produces longer analgesia and require less number of doses of rescue analgesics than 150 mg Pregabalin, this dose produces more side effects like dizziness, sedation, visual disturbance and headache post operatively.

Keywords: Pre-emptive analgesia, Pregabalin, Gynaecological surgeries, Postoperative pain

How to cite : Patel P M, Panchal R D, Patel B M, A randomized placebo controlled trial on evaluation of the efficacy of two different doses of pregabalin as a pre-emptive analgesia in gynaecological surgeries. Indian J Clin Anaesth 2016;3(4):576-582

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