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Comparison of haloperidol with ondansetron in preventing post-operative nausea and vomiting after laparoscopic abdominal surgeries

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Original Article

Author Details : Pradeep R, Amitha S, KV Srinivasan

Volume : 3, Issue : 4, Year : 2016

Article Page : 562-567

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Abstract

Background: Post-operative nausea and vomiting (PONV) is one of the commonest complications after general anesthesia despite advances in anesthesia techniques and newer anti-emetics.
PONV can result in other adverse events like aspiration pneumonitis, dehydration, disruption of surgical sutures.
Objectives: To compare the efficacy of haloperidol (2mg intravenous) with ondansetron 4mg intravenous in preventing PONV after laparoscopic abdominal surgeries(cholecystectomy, ovarian cystectomy, diagnostic laparoscopy).
Methods: A clinical, randomized, double blind study was conducted on ninety female patients who were admitted to Victoria and Bowring hospital, Bangalore, Karnataka. They were randomly grouped into three groups of thirty each by closed envelope technique. Group A received ondansetron 4mg intravenous, Group B received 2ml normal saline intravenous, Group C received Haloperidol 2mg intravenous, thirty minutes before the end of the surgery. Patients were followed up in the post-operative period for 24 hours and PONV, sedation, need for rescue anti-emetic and hemodynamic parameters were assessed. They were evaluated statistically using Chi-square, Fisher Exact and ANOVA tests.
Results: The patients in the Ondansetron 4mg group had lower incidence of vomiting than haloperidol 2mg group, but not statistically significant. Whereas, the incidence of nausea is similar in both ondansetron and haloperidol group with six (20%) patients each. And only two (6.6%) patients in haloperidol group had nausea in 0 to 2 hours in the post-operative period than compared to ondansetron group which had four (13.3%) patients in the same period. And also Ondansetron 4mg didn’t show any added advantage with respect to side effects, nausea and usage of rescue anti-emetic when compared to Haloperidol 2mg group.
Conclusion: We conclude that Ondansetron 4mg is not having significant advantage over Haloperidol 2mg in preventing PONV after laparoscopic abdominal surgeries.

Keywords: Aspiration pneumonitis, dehydration, haloperidol, ondansetron, nausea, vomiting, laparoscopic abdominal surgeries, rescue anti-emetic

How to cite : Pradeep R, Amitha S, Srinivasan K, Comparison of haloperidol with ondansetron in preventing post-operative nausea and vomiting after laparoscopic abdominal surgeries. Indian J Clin Anaesth 2016;3(4):562-567

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