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Evaluation of the efficacy of pre-operative oral pregabalin in attenuating haemodynamic response to laryngoscopy and intubation and on post-operative pain in patients undergoing elective surgery under

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Author Details : Ritwik Chakraborty, Ragi Jain, Rashmi Sharma

Volume : 3, Issue : , Year : 2016

Article Page : 419-426

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Abstract

Objective: Haemodynamic response to airway instrumentation is a hazardous complication of general anaesthesia. We evaluated the efficacy of preoperative 150 mg of oral pregabalin in attenuating haemodynamic response to laryngoscopy and endotracheal intubation as well as its efficacy in post-operative analgesia.
Methods: In this randomized double blind placebo controlled study 50 patients between 18-60 years, ASA grade I & II, of both genders were randomly divided into two groups of 25 patients. Group P received oral pregabalin 150 mg & Group C received placebo, 1hour prior to surgery. Anaesthesia technique was standardized and both groups were assessed for haemodynamic changes during laryngoscopy and postoperatively for level of sedation and pain. Statistical analysis was done using SPSS 17.
Results: There was significantly less increase in systolic, diastolic and mean blood pressure in group p following intubation when compared to group c (p= 0.02, 0.03, 0.02 respectively). Preoperative & post-operative sedation scores were relatively higher after pregabalin premedication. Group p also had reduced analgesic consumption as compared to group c (p=0.04).
Conclusion: This study shows that premedication with 150 mg of oral pregabalin safely attenuates haemodynamic responses to laryngoscopy & intubation & decreases post-operative pain with acceptable levels of sedation.

Keywords: Haemodynamic response, Pregabalin, laryngoscopy, Intubation, Sedation, Analgesia

How to cite : Chakraborty R, Jain R, Sharma R, Evaluation of the efficacy of pre-operative oral pregabalin in attenuating haemodynamic response to laryngoscopy and intubation and on post-operative pain in patients undergoing elective surgery under. Indian J Clin Anaesth 2016;3():419-426

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