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Comparison of effect of perioperative infusion of lidocaine vs dexmedetomidine on post-operative pain in patients undergoing laparoscopic cholecystectomy

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Original Article

Author Details : Anam Rizwan, Shirin Parveen*, Harpreet Kaur, Kirtika Yadav, Harshita Singh, Karanvir S Sidhu

Volume : 12, Issue : 1, Year : 2025

Article Page : 112-117

https://doi.org/10.18231/j.ijca.2025.017

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Abstract

Background: Growing concerns regarding opioid-related side effects and complications have prompted alternative analgesic modalities for post-operative pain in laparoscopic cholecystectomy. This study aimed to compare the efficacy of Lidocaine and Dexmedetomidine infusions administered intraoperatively by evaluating post-operative VAS scores, hemodynamic parameters, recovery profiles, total number of rescue analgesics required, and any side effects of the study drugs between the two groups.
Materials and Methods: Interventional, double-blind, randomized study on 66 ASA I/II class patients aged 18 to 60 years of both genders. These Patients were randomized to Group L (Lidocaine) and Group D (Dexmedetomidine). Hemodynamic Parameters were noted at pre-defined time frames intra/post-operatively. Post-operative Visual Analogue Scale Score and Richmond Agitation Sedation Score monitoring was done.
Results: The study did not result in any significant hemodynamic event, indicating the safety of both Lidocaine and Dexmedetomidine. Moreover, both drugs were found to be effective in managing post-operative pain but mean VAS was found to be significantly lower in Group D as compared to that in Group L at 120 min follow-up only (p<0> Conclusion: It can be inferred that perioperative infusion of both Lidocaine and Dexmedetomidine effectively delayed the post-operative rescue analgesic need, with similar recovery profiles. However, of the two, Dexmedetomidine had a slight edge over Lidocaine in terms of analgesic effect and recovery profile.
 

Keywords: Lidocaine, Dexmedetomidine, Post- operative pain, Laparoscopic cholecystectomy, Post- operative recovery.

How to cite : Rizwan A, Parveen S, Kaur H, Yadav K, Singh H, Sidhu K S, Comparison of effect of perioperative infusion of lidocaine vs dexmedetomidine on post-operative pain in patients undergoing laparoscopic cholecystectomy. Indian J Clin Anaesth 2025;12(1):112-117

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