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Effectiveness of intranasal versus intravenous dexmedetomidine for attenuation of hemodynamic responses of laryngoscopy and endotracheal intubation in patients undergoing general anaesthesia: Randomized controlled trial

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Original Article

Author Details : Kalyani Madhukarrao Deshmukh*, Sumita V Bhargava, Anjali R Bhure, Aishwarya Awadhut Mone, Kishor Rameshrao Dhoble, Aishwarya Avinash Rode

Volume : 12, Issue : 1, Year : 2025

Article Page : 50-58

https://doi.org/10.18231/j.ijca.2025.008

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Abstract

Aim and Objective: Attenuation of hemodynamic responses to laryngoscopy and intubation is major concern during conduct of general anaesthesia. This study compared the efficacy of intranasal versus intravenous Dexmedetomidine for attenuation of these hemodynamic responses.
Materials and Methods: Prospective double blind randomized controlled study was conducted on 90 participants randomized in 2 groups - Group DIN (n=45) received Intranasal Dexmedetomidine (1 µg/kg of 100µg/ml preparation) 40 minutes preinduction and Group DIV (n=45) received Intravenous Dexmedetomidine (0.5µg/kg of 200µg in 40 ml normal Saline infusion) 10 minutes preinduction.
Primary objective was to compare hemodynamic parameters in both groups every 10 min from drug administration till induction, at intubation and till 30 min postinduction. Secondary objective was to compare postoperative sedation in both groups at variable intervals. Data was analysed in statistical software Epi Info Software version 7.
Results: No significant hemodynamic response to laryngoscopy and intubation seen above baseline values in both groups. Group DIV showed lower values than DIN at laryngoscopy-intubation (P=0.0095) and postintubation phase till 7min (P=0.0016) in terms of MAP. No significant difference in postoperative sedation in both groups.
Conclusion: Intravenous and intranasal Dexmedetomidine equally attenuate hemodynamic responses to laryngoscopy and intubation during general anaesthesia with similar postoperative sedation. Intranasal Dexmedetomidine had steadier hemodynamics than intravenous Dexmedetomidine.
 

Keywords: Intravenous, intranasal, Dexmedetomidine, Laryngoscopy, Intubation, Hemodynamic response.

How to cite : Deshmukh K M, Bhargava S V, Bhure A R, Mone A A, Dhoble K R, Rode A A, Effectiveness of intranasal versus intravenous dexmedetomidine for attenuation of hemodynamic responses of laryngoscopy and endotracheal intubation in patients undergoing general anaesthesia: Randomized controlled trial. Indian J Clin Anaesth 2025;12(1):50-58

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