Indian Journal of Clinical Anaesthesia
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN:-2394-4781
Online ISSN:-2394-4994
CODEN : IJCACT
Original Article
Author Details :
Volume : 12, Issue : 1, Year : 2025
Article Page : 22-27
https://doi.org/10.18231/j.ijca.2025.004
Abstract
Background: The Endoscopic retrograde cholangiopancreatography (ERCP) procedure is utilized for diagnosis and treatment of various biliary and pancreatic disorders. A variety of different drugs with different doses have been used to provide sedation, although they are associated with distinctive pros and cons. Propofol is a widely used sedative agent due to its rapid onset and short duration of action, making it suitable for procedures like ERCP. However, its use is not devoid of risks, including respiratory depression and hypotension. Therefore, strategies to minimize propofol dosage are of clinical significance.
Materials and Methods: After obtaining institutional ethics committee approval and CTRI registration study was conducted on 150 patients posted for ERCP procedure, with random allocation into two groups of 75 in each group. One group received interventional drug and other group received placebo 3 minutes before the procedure. Cumulative propofol consumption in terms of µg/kg/min and incidence of desaturation, hypotension as well as sore throat within 24 hours was recorded.
Results: The results of the study demonstrated that total propofol consumption was significantly lower in the benzydamine hydrochloride group compared to the placebo group, with values of 144.1 ± 27.3 µg/kg/min versus 154.5 ± 30.7 µg/kg/min (p = 0.03). The incidence of desaturation was marginally lower in the intervention group (1.3%) compared to the placebo group (2.7%), although this difference was not statistically significant (p = 0.56). Similarly, the occurrence of hypotension was 9.3% in the benzydamine hydrochloride group and 12% in the placebo group (p = 0.59). Postoperative sore throat within 24 hours was reported in 9.3% of patients in the intervention group and 13.3% in the placebo group, but this difference also did not reach statistical significance (p = 0.44).
Conclusion: The study concluded that benzydamine hydrochloride gargles are effective in reducing the cumulative propofol requirement during ERCP procedures. This reduction may help minimize dose-related complications associated with propofol use.
Keywords: Propofol, Benzydamine hydrochloride, Sedation, Cumulative propofol, Endoscopic retrograde cholangiopancreatography (ERCP).
How to cite : Gaur B P S, Nayak L K, Das M, Mohapatra P S, Nath P, Efficacy of benzydamine hydrochloride on cumulative propofol consumption in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP): A randomized placebo-controlled trial. Indian J Clin Anaesth 2025;12(1):22-27
This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
