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A comparison of analgesic efficacy between oral pregabalin, gabapentin, and melatonin as non-opioid anaesthesia for robotic-assisted laparoscopic surgeries: A prospective randomized double-blinded clinical study

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Original Article

Author Details : Monica Daisy, Girimurugan Nagarajan, Nagapriya Nagendran*

Volume : 11, Issue : 4, Year : 2024

Article Page : 511-517

https://doi.org/10.18231/j.ijca.2024.093

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Abstract

Background: Opioid-sparing anesthesia is increasingly used in surgery, though effectiveness varies. Given the anxiety-pain correlation, anxiolytics like gabapentinoids and melatonin may offer benefits. This study compares the preemptive use of pregabalin, gabapentin, and melatonin for postoperative analgesia in robotic-assisted laparoscopic surgeries (RALS).
Aim and Objective: The aim of this study is to investigate postoperative analgesia in patients undergoing robotic-assisted laparoscopic surgeries under non-opioid anesthesia. The objectives are to evaluate perioperative hemodynamics, assess the perioperative sedation score during the surgical procedures, determine the requirement for rescue analgesia in the postoperative period, and measure the perioperative anxiety score in patients undergoing these surgeries.
Materials and Methods: Sixty patients, aged 18-60 with ASA PS grade 1 & 2 and BMI < 35> 4.
Results: Baseline characteristics were balanced among groups. Gabapentin significantly reduced VAS scores (1.25 ± 0.44) and extended time to rescue analgesia (9.48 ± 0.69 hours). Anxiety scores and Ramsay sedation scores (1.45 ± 0.51) were comparable, but Group G showed lower sedation. Hemodynamics remained stable.
Conclusion: Gabapentin improved postoperative pain outcomes in RALS, supporting its use for individualized pain management in these surgeries. Differences in pain intensity, time to rescue analgesia, and sedation levels highlight the need for personalized approaches. Further research in various surgical contexts is recommended to optimize perioperative care.
 

Keywords: Analgeasia, Pregabalin, Gabapentin, Non- opiod anasthesia, Robotic surgery, Robotic Laproscopy, Melatonin, Laproscopic surgery.

How to cite : Daisy M, Nagarajan G, Nagendran N, A comparison of analgesic efficacy between oral pregabalin, gabapentin, and melatonin as non-opioid anaesthesia for robotic-assisted laparoscopic surgeries: A prospective randomized double-blinded clinical study. Indian J Clin Anaesth 2024;11(4):511-517

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