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Assessment of effect of two different doses of dexmedetomidine infusion on emergence agitation and quality of recovery after nasal surgery

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Original Article

Author Details : Harsimran Kaur Riar, Harish Singh Koshyari*, Parul Jindal, Vinish Kumar Agrawal

Volume : 11, Issue : 3, Year : 2024

Article Page : 354-360

https://doi.org/10.18231/j.ijca.2024.067

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Abstract

Background: To evaluate two different doses of dexmedetomidine infusion on emergence agitation and measurement of hemodynamics, bispectral index, cortisol levels, and quality of recovery in patients who underwent nasal surgery under general anaesthesia.
Materials and Methods: 94 individuals of either sex between the ages of 18 and 65 who experienced nasal surgery under general anesthesia were split into two groups for this randomized experimental study. Before induction, each group received loading doses of dexmedetomidine (DEX) infusion at a rate of 1 µg/kg over a period of 10 minutes. Group B underwent a standard induction and then received an infusion of 0.4?g/kg/h of dexmedetomidine every hour until they were extubated, while group A received an infusion of 0.8?g/kg/h. Sevoflurane was employed for maintenance. During emergence, the frequency of agitation, cough hemodynamic parameters, and recovery traits were assessed. Patients received the Quality of Recovery (QoR-40) questionnaire 24 hours following surgery.
Results: The hemodynamic reaction to laryngoscopy and intubation was blunted and the intubating circumstances were improved by both doses equally well. Group A's intraoperative mean PR and MAP were significantly (P<0 p=0.001).> Conclusion: Although a greater dose of DEX may have more hemodynamic adverse effects, it may also reduce the incidence of emergent agitation, the surgical stress response, and a smoother recovery profile.
 

Keywords: Dexmedetomidine, Emergence agitation, Nasal surgery, Quality of recovery (QoR40).

How to cite : Riar H K, Koshyari H S, Jindal P, Agrawal V K, Assessment of effect of two different doses of dexmedetomidine infusion on emergence agitation and quality of recovery after nasal surgery. Indian J Clin Anaesth 2024;11(3):354-360

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