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Pre-eminence of oral clonidine when juxtaposed with oral midazolam as pre-anaesthetic medication in children: a prospective randomised double blind study

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Original Article

Author Details : Anil Shetty, Vinaybabu Kurian, Anand Bangera, Nikil M.P

Volume : 3, Issue : 2, Year : 2016

Article Page : 144-147

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Abstract

Background & Objectives: Drugs administered before anaesthesia to decrease anxiety and to obtain a smoother induction, maintenance and emergence from anaesthesia is a part of preanaesthetic medication. Clonidine, a central ?₂ agonist and Midazolam, a benzodiazepine, are among drugs used as preanaesthetic medication which plays a vital role in producing sedation and reducing anxiety especially in children. Hence, the aim of this study was to evaluate the role of oral Clonidine and oral Midazolam as an ideal preanaesthetic medication in children to produce sedation and reduce anxiety.
Methods: A prospective randomised double blind study was done involving 70 children (2-10) years scheduled for elective surgery between the period of January 2014 to July 2015 in Department of Anaesthesia, K.S. Hegde Medical College and Hospital, K.S.Hegde Medical (Affiliated to NITTE university), Deralakatte, Mangalore, Karnataka, India. They were randomly divided in to two groups as group A (Oral Midazolam, 0.5mg/kg) and group B (Oral Clonidine, 4mcg/kg). The drugs were administered to the subjects 45 minutes before induction of anaesthesia and evaluated for sedation and anxiety based on scores as per protocol.
Results: Anxiety scores showed a decrease in both Midazolam and Clonidine group with a value of 3.35(p<0.001) and 4.12(p<0.00) respectively. Similarly, sedation scores showed an increase in both Midazolam and  Clonidine group with a value of 4.25(p<0.001)  and 5.51(p<0.000)  respectively.
Interpretation & conclusions: Oral Clonidine (4mcg/kg) is a potent and efficacious preanaesthetic medication in children when juxtaposed with oral Midazolam (0.5mg/kg) in producing sedation and reducing anxiety along with analgesic sparing effect.

Keywords: Anxiety, Clonidine, Midazolam, Pre-anaesthetic, Sedation

How to cite : Shetty A, Kurian V, Bangera A, M.p N, Pre-eminence of oral clonidine when juxtaposed with oral midazolam as pre-anaesthetic medication in children: a prospective randomised double blind study. Indian J Clin Anaesth 2016;3(2):144-147

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