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Evaluation of efficacy of low dose IV ketamine for prevention of pain associated with IV propofol injection

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Original Article

Author Details : Medha Akhilesh Sangawar, Mohana Sharadchandra Shewalkar*, Puja Madhukar Shinde, Soma Chandrashekharan Cham, Akshay Nagorao Shende

Volume : 10, Issue : 3, Year : 2023

Article Page : 235-241

https://doi.org/10.18231/j.ijca.2023.050

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Abstract

Background: Propofol is a widely used intravenous anaesthetic that is known to cause distressing local pain at the site of injection. Ketamine pretreatment is one of the methods proposed to attenuate Propofol injection pain due to its local anaesthetic properties.The present study was undertaken to evaluate the efficacy of low dose (100 mcg/kg) I.V. Ketamine in decreasing I.V. Propofol injection pain by using McCrirrick and Hunter scale.
Materials and Methods: 72 adult patients of ASA Physical status 1 and 2 of either sex undergoing elective surgical procedure under general anaesthesia were randomly allocated into two groups.Group- A (n=36): Pre-treatment with Ketamine 100µg/kg (1ml) and Group- B (n=36): pre-treatment with 0.9% Normal Saline (1ml).
Results: Comparison between group A and group B using McCrirrick and Hunter Evaluation Scale at 5,10 and 15 seconds intervals were statistically highly significant (p value<0> Conclusion: I.V. Ketamine in a dose of 100mcg/kg with tourniquet as pretreatment before Propofol was useful in significantly reducing the incidence and severity of pain without any adverse haemodynamic effect.
 

Keywords: Anaesthesia, Ketamine, McCrirrick and hunter scale, Pretreatment, Propofol.

How to cite : Sangawar M A, Shewalkar M S, Shinde P M, Cham S C, Shende A N, Evaluation of efficacy of low dose IV ketamine for prevention of pain associated with IV propofol injection. Indian J Clin Anaesth 2023;10(3):235-241

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