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Effect of oral gabapentin as pre-emptive analgesia in total abdominal hysterectomy- A randomised prospective placebo controlled study

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Original Article

Author Details : Sujay J. N*, Prakash B.C , Riyaj Ahmad Kalaburgi

Volume : 9, Issue : 4, Year : 2022

Article Page : 461-466

https://doi.org/10.18231/j.ijca.2022.093

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Abstract

Background: The postoperative period is an integral part of the surgical experience of the patient. Post-operative pain affects recovery from anaesthesia and surgery. Pre-emptive use of gabapentin speeds up recovery by decreasing post-operative pain.
Objectives: The objectives of the study were to evaluate the effect of oral gabapentin on post-operative pain scores, the request time for first analgesia and the total fentanyl requirement in 12 hours in patient undergoing total abdominal hysterectomy under epidural anaesthesia.
Materials and Methods: Eighty four patient of ASA grade I and II aged 40 to 60 years, scheduled for total abdominal hysterectomy under epidural anaesthesia were included in the study. Each patient was assigned into two groups (Gabapentin group, group G or Placebo group, group P) of 42 each. Participants in the study were administered 2 capsules (either gabapentin or placebo) one hour before surgery with sips of water. 15ml of Ropivacaine 0.75% was administered into epidural space through 20 gauge epidural catheter. Pain was evaluated post-operatively using visual analogue scale (VAS). Inj. Fentanyl 30 mcg was administered through epidural catheter as rescue analgesia when patients complained of pain.
Results: It was observed that Pain scores were notably lesser in group G as compared to group P at all time points (P<0> Conclusions: We conclude that the pre-emptive administration of oral gabapentin 600mg significantly reduces pain scores, prolongs the time at which patient requires rescue analgesia and the amount of fentanyl needed was significantly reduced.
 

Keywords: Gabapentin, Post- operative pain, Analgesia, Visual analogue scale.

How to cite : Sujay J. N, B.c P, Kalaburgi R A, Effect of oral gabapentin as pre-emptive analgesia in total abdominal hysterectomy- A randomised prospective placebo controlled study. Indian J Clin Anaesth 2022;9(4):461-466

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