---

A prospective study evaluating the effect of nebulised lidocaine on haemodynamic responses during nasotracheal intubation

Full Text PDF

---

Original Article

Author Details : Reetu Verma, Shivani Gaurav*, Hemlata Verma, Sateesh Verma, Brij Kuswaha, Ajay Kumar Chaudhary, Dinesh Singh

Volume : 9, Issue : 4, Year : 2022

Article Page : 439-444

https://doi.org/10.18231/j.ijca.2022.089

Suggest article by email

Get Permission

Abstract

Background: Laryngoscopy and endotracheal intubation result in a significant increase in haemodynamic stress response which is well tolerated by healthy patients but in patients with significant coronary artery or cerebrovascular diseases, if it is not prevented adequately may lead to myocardial ischemia and cerebral haemorrhage.
Objectives: This prospective comparative study was conducted between August 2019-July 2020 to study the effect of nebulised lidocaine on haemodynamic stress responses (primarily mean arterial blood pressure also heart rate, systolic blood pressure and diastolic blood pressure)  during nasotracheal intubation.
Materials and Methods: 94 patients who underwent head and neck surgery under general anaesthesia requiring nasotracheal intubation were randomised into two groups using a computational random number, Group A (control group): was nebulised with 5 ml of normal saline. Group B: was nebulised with 5ml of Lidocaine 4% solution. Heart rate(HR), systolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial blood pressure(MAP), and SpO2  were observed before and after nebulisation, just before intubation, immediately after intubation and at 3, 5 10 min after intubation.
Results: On comparing SBP, DBP, MAP and heart rate immediately after intubation with pre-intubation values, there was a significant surge in both groups but an increase in the control group was more in comparison to the lidocaine group(p<.05). Thereafter MAP, SBP, DBP and HR gradually decreased till the duration of study i.e. 10 minutes.
Conclusion: The administration of nebulised 4% Lidocaine inhalation before induction attenuates cardiovascular response (primarily in terms of MAP also SBP, DBP and HR) that occurs due to nasotracheal intubation.

Keywords: Haemodynamic, Lidocaine, Nebulisation, Nasotracheal intubation.

How to cite : Verma R, Gaurav S, Verma H, Verma S, Kuswaha B, Chaudhary A K, Singh D, A prospective study evaluating the effect of nebulised lidocaine on haemodynamic responses during nasotracheal intubation. Indian J Clin Anaesth 2022;9(4):439-444

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.