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A randomized controlled study to compare the efficacy of amyl meta cresol-2, 4-dichlorobenzyl alcohol lozenges Vs warm saline gargles Vs control in the prevention and treatment of post-operative sore throat after endotracheal intubation

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Original Article

Author Details : Munira A Dilawer, Sandeep Mutha, Ajit Gaikwad, Deepak Phalgune*

Volume : 9, Issue : 1, Year : 2022

Article Page : 81-88

https://doi.org/10.18231/j.ijca.2022.017

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Abstract

Introduction: The incidence of a post-operative sore throat (POST) varied from 21%–100% in intubated patients. Numerous non-pharmacological and pharmacological measures have been used for attenuating POST with variable success. The aim of the present study was to compare the efficacy of amyl meta cresol-2,4-dichlorobenzyl alcohol (AMC-2,4-DCBA) lozenges against warm normal saline (0.9%) gargles versus control in preventing and treating POST after extubation of the patients who have undergone surgical procedures under general anaesthesia.
Materials and Methods: This single-blind randomised controlled study was conducted in 120 patients. Group S patients received one honey and lemon-flavoured AMC-2,4-DCBA lozenge. Group G and Group C patients received warm normal saline and distilled water for gargling respectively. Assessment of POST was carried out at 1 h, 12 h and 24 h. The primary outcome measure was to compare the degree of sore throat whereas secondary outcome measure was to compare patient comfort in terms of relief of symptoms. Comparison of quantitative and qualitative variables was done using analysis of variance test and chi-square test/Fisher’s exact test respectively.
Results: There was no statistically significant difference between Group S, Group G and Group C in relation to Ramsay sedation score, supplemental analgesics given, three-point assessment score at 1 h, 12 h, and 24 h. AMC-2,4-DCBA lozenges offered the maximum benefit in terms of patient comfort of POST symptoms at the end of 24 h post-surgically.
Conclusions: Amyl meta cresol-2,4-dichlorobenzyl alcohol lozenges and warm normal saline gargles did not show a significant benefit in relieving post-operative sore throat in the post-surgical period as compared to the placebo.
 

Keywords: Amyl meta cresol-2, 4-dichlorobenzyl alcohol lozenges, Distilled water, Post-operative sore throat, Ramsay sedation scale, Warm normal saline

How to cite : Dilawer M A, Mutha S, Gaikwad A, Phalgune D, A randomized controlled study to compare the efficacy of amyl meta cresol-2, 4-dichlorobenzyl alcohol lozenges Vs warm saline gargles Vs control in the prevention and treatment of post-operative sore throat after endotracheal intubation. Indian J Clin Anaesth 2022;9(1):81-88

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