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Comparison of safety and efficacy of tranexamic acid, tranexamic acid with adrenaline, and adrenaline alone in wound infiltration locally for postoperative bleeding in total knee arthroplasty

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Original Article

Author Details : Anita Surana*

Volume : 9, Issue : 1, Year : 2022

Article Page : 49-55

https://doi.org/10.18231/j.ijca.2022.011

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Abstract

To compare the efficacies of intra-articular applications of tranexamic acid and adrenaline on postoperative bleeding after total knee arthroplasty. Introduction: Currently, total knee arthroplasty (TKA) is considered the treatment of choice in advanced stages of knee osteoarthritis. Despite advances in surgical and anaesthetic techniques, TKA is still associated with a considerable amount of perioperative blood loss. Tranexamic acid (TXA) is an antifibrinolytic drug whose administration during the perioperative period either by intravenous route or topically applied to the surgical field has been shown to reliably reduce blood loss and need for transfusion in patients undergoing total knee arthroplasty. Material and Method: The single-center, double-blind, controlled study was undertaken after approval from the institutional ethical committee. we included 60 pts in three groups of 20 pts each, Group A pts received 1000mg of tranexamic acid intra-articular and peri-articular, diluted with 10 ml Ns to make it 20 ml, Group B pts received 1000mg tranexamic acid +1 ml of 1:1000 Adrenalin + 9 ml of Ns and Group C pts received1 ml of 1:1000 Adrenalin diluted to 19 ml with Ns at the time of wound closure. We compared blood loss in all the three groups in first 24 hrs, and fall in Hb level from the preoperative level at 4hrs and 24 hrs. post-operatively. Also observed the no of blood transfusions required in all three groups in 48 hrs. Also noted any untoward effects like infection, deep vein thrombosis, etc. Results: Fall in Hb level was also less in Grp B (1.22±0.45), as compared to Grp A (1.56±0.3,) and Grp C (1.65±0.68) at 4 hrs. post-operative and it was statistically significant (P-value 0.0219). Total 24 hrs. fall in Hb was 2.14±0.31 in Grp A, 1.18±1.14 in Grp B, and 2.52±0.19in Grp C which was also statistically significant (P-value 0.005) The total blood loss in 24 hrs. is 324+-81.93ml in Grp B, 370±72.±72.6 ml in Grp A and410.30 ml in Grp C which was statistically significant (P value 0.005). The no of blood transfusion required in 48 hrs. is 5 Units in Grp C as compared to 3 units in Grp A and 2 units in Grp B. Conclusion We came to the conclusion that TXA given as local infiltration is an effective and safe method of preventing postoperative blood loss and the addition of Adrenaline as an adjuvant further adds to its effect without much untoward effect.
 

Keywords: Knee-Arthroplasty, Tranexamic acid, Adrenaline, Haemostasias, Blood loss.

How to cite : Surana A, Comparison of safety and efficacy of tranexamic acid, tranexamic acid with adrenaline, and adrenaline alone in wound infiltration locally for postoperative bleeding in total knee arthroplasty. Indian J Clin Anaesth 2022;9(1):49-55

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