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Nalbuphine versus dexmedetomidine for attenuation of haemodynamic response to laryngoscopy and intubation: A randomised double blind comparative study

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Original Article

Author Details : Akanksha Rathore*, Sujata Chaudhary, Mahendra Kumar, Rashmi Salhotra

Volume : 8, Issue : 4, Year : 2021

Article Page : 579-585

https://doi.org/10.18231/j.ijca.2021.123

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Abstract

Background: Laryngoscopy and intubation are noxious stimuli which result in marked sympathetic response. However, literature search did not reveal any study comparing nalbuphine and dexmedetomidine for attenuation of haemodynamic response to laryngoscopy and intubation.
Materials and Methods: After Institutional Ethical Committee approval and written informed consent, 80 ASA I and II patients were randomised in two groups of 40 each. Group N received 0.2 mg/kg of nalbuphine; group D received 1 µg/kg dexmedetomidine over a period of 10 min. Anaesthesia was induced as per standard general anaesthesia practice. Haemodynamic parameters [Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), & Mean Arterial Pressure (MAP)] were recorded at baseline, 0, 1, 3, 5, 10, and 15 min following intubation. Patients were also observed for any side effects of the study drugs.
Results: There was a significant decrease (p<0> Conclusion: Dexmedetomidine was found to be more effective in attenuating haemodynamic response to laryngoscopy and intubation as compared to nalbuphine.

Keywords: Dexmedetomidine, Nalbuphine, Laryngoscopy, Intratracheal, Intubation.

How to cite : Rathore A, Chaudhary S, Kumar M, Salhotra R, Nalbuphine versus dexmedetomidine for attenuation of haemodynamic response to laryngoscopy and intubation: A randomised double blind comparative study. Indian J Clin Anaesth 2021;8(4):579-585

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