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Comparison of intrathecal hyperbaric bupivacaine, isobaric levobupivacaine and isobaric ropivacaine with fentanyl as adjuvant in knee arthroscopy: A randomised controlled study

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Original Article

Author Details : Neha Yadav*, Sujata Chaudhary, Divya Gahlot, Rashmi Salhotra

Volume : 7, Issue : 4, Year : 2020

Article Page : 594-599

https://doi.org/10.18231/j.ijca.2020.108

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Abstract

Background and Aim: To compare the efficacy of intrathecal 0.5% hyperbaric bupivacaine, 0.5% isobaric levobupivacaine and 0.5% isobaric ropivacaine with fentanyl as adjuvant for outpatient knee arthroscopic surgeries.
Material and Methods: This prospective, randomized, double-blind study was conducted on 60 ASA I/II patients between 18-60 years, scheduled for knee arthroscopy under subarachnoid block. Patients were randomised into three groups; group BF: 10 mg 0.5% hyperbaric bupivacaine (2 ml), group LF: 10 mg 0.5% isobaric levobupivacaine (2 ml), group RF: 10 mg 0.5% isobaric ropivacaine (2 ml). In addition, each patient received fentanyl 25 mg (0.5 ml) as an adjuvant to the local anaesthetic (total intrathecal volume 2.5 ml in all three groups). The sensory and motor block characteristics, time to ambulation and discharge were recorded. Demographic profile, sensory and motor block characteristics were compared using one way ANOVA followed by Tukey’s test and hemodynamic parameters were compared using repeated measure ANOVA. Dunnett’s test was applied wherever required. Qualitative data was compared using Chi square or Fisher’s exact test. P-value <0> Results: Mean time to ambulation and discharge was significantly less in group RF (10.10 ± 3.63 hr) compared to 14.80±3.63 hr in group BF and 12.40±2.30 hr in group LF (p<0 p=0.522).> Conclusion: Isobaric ropivacaine with fentanyl is better drug combination than isobaric levobupivacaine with fentanyl or hyperbaric bupivacaine with fentanyl as spinal anaesthetic for outpatient knee arthroscopic surgery.

Keywords: Bupivacaine, levobupivacaine, Ropivacaine, Fentanyl, Knee arthroscopy, Ambulation, Day care.

How to cite : Yadav N , Chaudhary S , Gahlot D , Salhotra R , Comparison of intrathecal hyperbaric bupivacaine, isobaric levobupivacaine and isobaric ropivacaine with fentanyl as adjuvant in knee arthroscopy: A randomised controlled study. Indian J Clin Anaesth 2020;7(4):594-599

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