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Optimum Dose of Epidural Tramadol Hydrochloride for Post Operative Analgesia

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Original Article

Author Details : Suhail Sidiq, Umar Qadir Bacha, Abdul Waheed Mir, Rayees Najib, Mohammad Akbar Shah

Volume : 2, Issue : 4, Year : 2015

Article Page : 262-268

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Abstract

Background: Tramadol hydrochloride is a centrally acting analgesic with a combination of opioid and non-opioid receptor mechanisms and a benign side effect profile. The epidural route appears to be a logical choice because of the direct effect in the transmission and processing of pain. The purpose of this study was to find out the effective dose of epidurally administered tramadol for postoperative analgesia in urological surgical patients.
Method: 60 healthy patients of American Society of Anesthesiologists(ASA) physical status classification I and II, with age ranging from 20-60 years, scheduled to undergo elective surgeries were equally divided into 3 groups(I,II & III) receiving 1mg/kg, 2mg/kg and 3mg/kg of tramadol hydrochloride epidurally respectively post-operatively in PACU. Time to first request for analgesia and side effects like nausea, vomiting, dizziness and pruritus were also noted.
Results: There was a statistically significant difference in the period of postoperative pain relief in Group-I (6.8±2.3 hours), Group-II(14±8 hours) and Group-III(21.4±3.7 hours). There was significant increase in postoperative nausea and vomiting in group III (40%) as compared to group I (10%) and group II (5%).
Conclusion: These findings suggest that 2mg/kg body weight of epidural tramadol is an optimum dose for postoperative analgesia without increase in side effects. 3mg/kg dose can also be used with appropriate anti emetics to decrease the incidence of PONV with this dose.

Keywords: Analgesia, Epidural, Tramadol, Urological surgeries

How to cite : Sidiq S, Bacha U Q, Mir A W, Najib R, Shah M A, Optimum Dose of Epidural Tramadol Hydrochloride for Post Operative Analgesia. Indian J Clin Anaesth 2015;2(4):262-268

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