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Comparative evaluation of levobupivacaine-fentanyl and ropivacaine - fentanyl in epidural anaesthesia in lower limb orthopaedic surgeries in elderly patients

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Original Article

Author Details : Gurjit Singh Gandhi, Tripat Kaur Bindra*, Parmod Kumar, Bindu Kaushal

Volume : 7, Issue : 2, Year : 2020

Article Page : 324-328

https://doi.org/10.18231/j.ijca.2020.058

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Abstract

Background: Epidural blockade with levobupivacaine and ropivacaine, the two new long-acting local
anaesthetics, have been preferred in elderly due to low cardiac and central nervous system toxicity.
Materials and Methods : A randomized prospective study was conducted on 100 patients having age 60-85
yr of ASA physical status I, II and III admitted for elective lower limb orthopaedic surgeries under epidural
anesthesia. Patients were randomly divided into two groups, Group A received epidural levobupivacaine
0.5% (13ml) and Group B received ropivacaine 0.75% (13ml), both with fentanyl 100 mg (2ml). Time of
onset, peak level and time to attain peak level of the sensory block & time of regression upto two segment
along with duration of analgesia were noted. Onset time and duration of motor block, hemodynamics and
adverse effects were also compared in the two groups.
Results: Onset time of sensory block in group A was 5.740.66 minutes, while it was 5.68+0.62 minutes
in group B. Maximum sensory block was attained in 8.58 0.81 minutes in group A and 8.52 +0.84
minutes in group B. 134.2+8.10 minutes were taken for two segment regression in group A, while the
time taken in group B was 134+10.88 minutes. Motor blockade mean onset time was 20+3.35 minutes
and 20.2+3.64 minutes in group A and group B respectively. The mean duration of motor block in group
A was 248.4+13.60 minutes and 247.8+13.29 minutes in group B. The mean duration of analgesia was
382+18.63 minutes in group A, while it was 382.4+15.98 minutes in group B. Results were comparable
with regards to sensory and motor blockade parameters, hemodynamics and adverse effects.
Conclusion: Both 0.5% levobupivacaine and 0.75% ropivacaine with fentanyl as adjuvant are effective
and comparable for epidural anaesthesia in elderly patients with regard to sensory and motor block
characteristics along with similar hemodynamic profile.

Keywords: Levobupivacaine, Ropivacaine, Bupivacaine, Epidural blockade.

How to cite : Gandhi G S, Bindra T K, Kumar P , Kaushal B, Comparative evaluation of levobupivacaine-fentanyl and ropivacaine - fentanyl in epidural anaesthesia in lower limb orthopaedic surgeries in elderly patients. Indian J Clin Anaesth 2020;7(2):324-328

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