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Comparison of etomidate and propofol for moderate sedation during ERCP: A randomized clinical study

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Original Article

Author Details : Karishma Jain, Namita Gupta*, Durga Jethava

Volume : 6, Issue : 4, Year : 2019

Article Page : 587-591

https://doi.org/10.18231/j.ijca.2019.114

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Abstract

Introduction: Endoscopic retrograde cholangio - pancreatography (ERCP) is the solution to many biliary
problems from a diagnostic solution to complex therapeutic interventions. Etomidate is considered safe
as an induction agent in hemodynamically unstable patients and can be considered as an alternative to
propofol. In this study, we compared etomidate with propofol during ERCP in respect of hemodynamic
stability and early recovery of patients.
Materials and Methods: The study is randomized, double blinded, comprising of 60 patients i.e 30
patients in each group undergoing therapeutic ERCP. In the procedure room, standard monitoring was
done. All patients received loading dose of dexmedetomidine 10 mins before initiation of the procedure.
After 10 min group P(Propofol) patients received inj propofol bolus dose (2mg/kg/min)) and then infusion
of propofol at 100- 150mg/kg/min. Group E(Etomidate) patients received inj etomidate (0.3mg/kg/min)
and then infusion of etomidate started at 8- 10mcg/kg/min. Depth of sedation was measured by using
Ramsay sedation score 0.
Results: Requirement of rescue analgesia is more in group E (P=0.002 ) and recovery is also longer
in group E (P =0.01) Changes in heart rate and mean blood pressure from baseline is more in group
P(Propofol) than group E N Mean Std. Dev Minimum Maximum P value, Rescue drugs Propofol 10 23.00
4.21 20.00 30.00 0.002 (S), Etomidate 1438.57 13.78 15.00 60.00, Induction time Propofol 30 1.73 0.63
1.00 2.80 0.001 (S), Etomidate 30 2.65 0.54 2.00 3.60, Duration Propofol 30 37.66 11.42 20.00 65.00 –,
Etomidate 30 37.66 11.42 20.00 55.00, Recovery time Propofol 30 4.96 4.58 1.00 15.00 0.01 (S), Etomidate
30 7.73 3.45 2.00 13.00.

Keywords: Etomidate, Propofol, Moderate sedation ERCP.

How to cite : Jain K, Gupta N, Jethava D, Comparison of etomidate and propofol for moderate sedation during ERCP: A randomized clinical study. Indian J Clin Anaesth 2019;6(4):587-591

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